Introduction: Huntington’s disease is a progressive autosomal dominant neurodegenerative disorder characterized by a triad of clinical features affecting an individual’s cognitive, physical, and psychological functions. Symptoms typically manifest in middle age, between 30 and 40 years, leading to death within one to two decades after the onset of neurological deterioration. This incurable disease renders patients entirely dependent on care, significantly impacting family members, friends, and close associates. Patient care focuses on alleviating symptoms, maintaining functional ability, and preserving quality of life. It is provided by a multidisciplinary healthcare team that includes pharmacological and nonpharmacological interventions. Objective: This paper aims to conduct a literature review and present a comprehensive overview of nursing care processes for patients with Huntington’s disease. Conclusion: Guidelines for caring for patients with Huntington's disease provide a foundation for a multidisciplinary approach and enhance patient quality of life, emphasizing comfort, safety, and dignity. As key team members, involving specialized nurses contributes to reducing hospitalization durations, optimizing care levels, and improving the quality of life for patients with Huntington’s disease.